Pertz Lab

Author ID

ORCID ID: 0000-0001-8579-4919
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2024

Vasundhara Rao, Benjamin Grädel, Lucien Hinderling, Jakobus Van Unen, Olivier Pertz Feedback regulation by the RhoA-specific GEF ARHGEF17 regulates actomyosin network disassembly bioRxiv

Lucien Hinderling, Guillaume Witz, Roman Schwob, Ana Stojiljkovic, Maciej Dobrzynski, Mykhailo Vladymyrov, Joel Frei, Benjamin Graedel, Agne Frismantiene, Olivier Pertz Convpaint - Interactive pixel classification using pretrained neural networks bioRxiv

Wojnacki J., Quassollo G., Bordenave M.D., Unsain N., Martínez G.F., Szala A.M., Pertz O.; Gundersen G.G., Bartolini F., Stefani F.D., Cáceres A., Bisbal M. Dual spatio-temporal regulation of axon growth and microtubule dynamics by RhoA signaling pathways. J Cell Sci. (2024)

Dobrzyński M., Grädel B., Gagliardi PA and Pertz O. Quantification of collective signalling in time-lapse microscopy images. Methods in Microscopy (2024)

Gagliardi P.A., Pertz O. The mitogen-activated protein kinase network, wired to dynamically function at multiple scales. Curr Opin Cell Biol. (2024)

Lu L., Guyomar T., Vagne Q., Berthoz R., Torres-Sánchez A., Lieb M., Martin-Lemaitre C., Van Unen K., Honigmann A., Pertz O., Riveline D., Salbreux G. Polarity-driven three-dimensional spontaneous rotation of a cell doublet. Nat. Phys. (2024).

Spontaneous rotations in epithelia as an interplay between cell polarity and RhoA activity at boundaries. Lo Vecchio S., Pertz O, Szopos M., Navoret L., Riveline D. Spontaneous rotations in epithelia as an interplay between cell polarity and boundaries. Nat. Phys. (2024).

Heydasch M., van Unen J., Hinderling L., Dobrzynski M., Pertz O. GTPase activating protein DLC1 spatio-temporally regulates Rho signaling. Elife (2024)

Pulfer A, Pizzagalli D.U., Gagliardi P.A., Hinderling L., Lopez P., Zayats P., Carrillo-Barbera P., Antonello P., Palomino-Segura M., Giusti A., Thelen M., Gambardella L.M., Murooka T.T., Pertz O., Krause R., Fernandez Gonzalez S. Transformer-based spatial-temporal detection of apoptotic cell death in live-cell imaging. Elife (2024)

2021

Gagliardi, P. A., Dobrzyński, M., Jacques, M. A., Dessauges, C., Ender, P., Blum, Y., ... & Pertz, O. (2021). Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival. Developmental Cell.

Jacques, M. A., Dobrzyński, M., Gagliardi, P. A., Sznitman, R., & Pertz, O. (2021). CODEX, a neural network approach to explore signaling dynamics landscapes. Molecular systems biology, 17(4), e10026.

Loewith, Robbie; Roux, Aurélien; Pertz, Olivier (2021). Chemical-Biology-derived in vivo Sensors: Past, Present, and Future. Chemical Biology of Membranes and Signaling. Vol. 75 No. 12

S. Lo Vecchio, O. Pertz, M. Szopos, L. Navoret, D. Riveline. Spontaneous rotations in epithelia as an interplay between cell polarity and RhoA activity at boundaries. bioRxiv

2019

Yannick Blum, Jan Mikelson, Maciej Dobrzyński, Hyunryul Ryu, Marc‐Antoine Jacques, Noo Li Jeon, Mustafa Khammash, Olivier Pertz (2019). Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling. Mol Syst Biol. 15: e8947, https://doi.org/10.15252/msb.20198947

Maciej Dobrzyński, Marc-Antoine Jacques, Olivier Pertz (2019). Mining single-cell time-series datasets with Time Course Inspector, Bioinformatics, , btz846, https://doi.org/10.1093/bioinformatics/btz846

Bagonis, Maria; Fusco, Ludovico; Pertz, Olivier; Danuser, Gaudenz (2019). Automated profiling of growth cone heterogeneity defines relations between morphology and motility. Journal of cell biology, 218(1), pp. 350-379. Rockefeller Institute Press 10.1083/jcb.201711023

Gagliardi PA, Pertz O. Developmental Erk Signaling Illuminated. Dev Cell. 2019 Feb 11;48(3):289-290. doi: 10.1016/j.devcel.2019.01.022.

2018

Song, Jiyoung; Ryu, Hyunryul; Chung, Minhwan; Kim, Youngtaek; Blum, Yannick; Lee, Sung Sik; Pertz, Olivier; Jeon, Noo Li (2018). Microfluidic platform for single cell analysis under dynamic spatial and temporal stimulation. Biosensors & bioelectronics, 104, pp. 58-64. Elsevier 10.1016/j.bios.2017.12.038

Hyunryul Ryu, Minhwan Chung, Jiyoung Song, Sung Sik Lee, Olivier Pertz & Noo Li Jeon. Integrated Platform for Monitoring Single-cell MAPK Kinetics in Computer-controlled Temporal Stimulations. Nature Scientific Reports volume 8, Article number: 11126 (2018)

2017

Kempf, Anissa; Boda, Enrica; Kwok, Jessica C F; Fritz, Rafael; Grande, Valentina; Kaelin, Andrea M; Ristic, Zorica; Schmandke, Andre; Schmandke, Antonio; Tews, Bjoern; Fawcett, James W; Pertz, Olivier; Buffo, Annalisa; Schwab, Martin E (2017). Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction. Developmental cell, 43(1), 24-34.e5. Cell Press 10.1016/j.devcel.2017.08.014

Dessauges, Coralie; Pertz, Olivier (2017). Developmental ERK Signaling Goes Digital. Developmental cell, 42(5), pp. 443-444. Cell Press 10.1016/j.devcel.2017.08.023

Blum, Yannick; Fritz, Rafael D; Ryu, Hyunryul; Pertz, Olivier (2017). Measuring ERK Activity Dynamics in Single Living Cells Using FRET Biosensors. In: Jimenez, Gerardo (ed.) ERK signaling. Methods in molecular biology: Vol. 1487 (pp. 203-221). Springer 10.1007/978-1-4939-6424-6_15

Riwal Lefort, Ludovico Fusco, Olivier Pertz & François Fleuret. Machine learning-based tools to model and to remove the off-target effect. Pattern Analysis and Applications volume 20, pages 87–100 (2017)

2016

Nölke, Thilo; Schwan, Carsten; Lehmann, Friederike; Østevold, Kristine; Pertz, Olivier; Aktories, Klaus (2016). Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT). Proceedings of the National Academy of Sciences of the United States of America - PNAS, 113(28), pp. 7870-7875. National Academy of Sciences NAS 10.1073/pnas.1522717113

Fusco, Ludovico; Lefort, Riwal; Smith, Kevin; Benmansour, Fethallah; Gonzalez, German; Barillari, Caterina; Rinn, Bernd; Fleuret, Francois; Fua, Pascal; Pertz, Olivier (2016). Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling. Journal of cell biology, 212(1), pp. 91-111. Rockefeller Institute Press 10.1083/jcb.201506018

Martin, Katrin; Reimann, Andreas; Fritz, Rafael D; Ryu, Hyunryul; Jeon, Noo Li; Pertz, Olivier (2016). Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamics. Scientific Reports, 6, p. 21901. Nature Publishing Group 10.1038/srep21901

Fritz, Rafael Dominik; Pertz, Olivier (2016). The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns. F1000Research, 5(749) F1000 Research Ltd 10.12688/f1000research.7370.1

2015

Ryu, Hyunryul; Chung, Minhwan; Dobrzyński, Maciej; Fey, Dirk; Blum, Yannick; Lee, Sung Sik; Peter, Matthias; Kholodenko, Boris N; Jeon, Noo Li; Pertz, Olivier (2015). Frequency modulation of ERK activation dynamics rewires cell fate. Molecular systems biology, 11(11), p. 838. EMBO Press 10.15252/msb.20156458

Fritz, Rafael Dominik; Menshykau, Denis; Martin, Katrin; Reimann, Andreas; Pontelli, Valeria; Pertz, Olivier (2015). SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion. Developmental cell, 35(1), pp. 78-92. Cell Press 10.1016/j.devcel.2015.09.002

Moretti, Francesca; Rolando, Chiara; Winker, Moritz; Ivanek, Robert; Rodriguez, Javier; Von Kriegsheim, Alex; Taylor, Verdon; Bustin, Michael; Pertz, Olivier (2015). Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth. Molecular and cellular biology, 35(11), pp. 2035-2050. American Society for Microbiology 10.1128/MCB.00133-15

2014

Martin, Katrin; Vilela, Marco; Jeon, Noo Li; Danuser, Gaudenz; Pertz, Olivier (2014). A growth factor-induced, spatially organizing cytoskeletal module enables rapid and persistent fibroblast migration. Developmental cell, 30(6), pp. 701-716. Cell Press 10.1016/j.devcel.2014.07.022

Fengos, Georgios; Schmidt, Alexander; Martin, Katrin; Fluri, Erika; Aebersold, Ruedi; Iber, Dagmar; Pertz, Olivier (2014). Spatial proteomic and phospho-proteomic organization in three prototypical cell migration modes. Proteome Science, 12, p. 23. BioMed Central 10.1186/1477-5956-12-23